The paradigm recently shifted on the Mac platform and we are now getting variants of the Mac Defender/Mac Protector Trojan horse and the perpetrators (my money is on a Russian mafia/hacker joint venture) and Apple are locked in an escalating battle of update and response. I expect more trouble now that the code is out in the wild and infecting numbers of computers- anti-virus/malware software might be a good idea.
http://en.wikipedia.org/wiki/Mac_DefenderI got one of these myself when searching in Google Images a few weeks ago and was surprised to see an installer screen for it in front of me. I force quit both the installer and Safari, then relaunched and reset Safari.There was no unusual activity in Activity Monitor and everything seemed OK, so I restarted the computer and checked both Login items (System Preferences, Accounts) and Activity Monitor (Utilities). A few hours later I heard about Mac Defender and went into Safari Preferences (General) and unchecked "Open 'safe' files after downloading" at the bottom of the pane.
As for which antivirus software to use, over the years I have had trouble with Norton Antivirus (poor Mac compatibility, opaque interface, system slowdowns - but reputedly cleaned up since 2009) and Sophos (incompatibility with 10.6, runaway invisible applications running in the background hard to uninstall)